Promethazine and daridorexant the two boost sedation. Modify Therapy/Monitor Carefully. Coadministration increases hazard of CNS melancholy, which can cause additive impairment of psychomotor overall performance and result in daytime impairment. clozapine decreases effects of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Observe. Prevents conversion of codeine to ... https://wockusa.com/product-category/codeine/